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Cannabinoid Synthases

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Characterisation of Cannabis accessions with regard to cannabinoid content in relation to other plant characters E. P. M. de Meijer, H. J. van der Kamp, F. A. van Eeuwijk Euphytica January 1992, Volume 62, Issue 3, pp 187–200 https://link.springer.com/article/10.1007/BF00041753   


First Direct Evidence for the Mechanism of Tetrahydrocannabinolic Acid Biosynthesis Futoshi Taura, Satoshi Morimoto, Yukihiro Shoyama, Raphael Mechoulam J. Am. Chem. Soc. 1995, 117, 9766-9767 http://pubs.acs.org/doi/abs/10.1021/ja00143a024     


The Inheritance of Chemical Phenotype in Cannabis sativa L. Etienne P. M. de Meijer, Manuela Bagatta, Andrea Carboni, Paola Crucitti, V. M. Cristiana Moliterni, Paolo Ranalli and Giuseppe Mandolino Genetics January 1, 2003 vol. 163 no. 1 335-346 http://www.genetics.org/content/163/1/335   


Potential of marker-assisted selection in hemp genetic improvement Giuseppe Mandolino, Andrea Carboni  Published 2004 in Euphytica https://link.springer.com/article/10.1007/s10681-004-4759-6   


The Gene Controlling Marijuana Psychoactivity MOLECULAR CLONING AND HETEROLOGOUS EXPRESSION OF Δ1-TETRAHYDROCANNABINOLIC ACID SYNTHASE FROM CANNABIS SATIVA L.* Supaart Sirikantaramas, Satoshi Morimoto, Yoshinari Shoyama, Yu Ishikawa, Yoshiko Wada, Yukihiro Shoyama and Futoshi Taura http://www.jbc.org/content/279/38/39767.full     


The inheritance of chemical phenotype in Cannabis sativa L. (II): Cannabigerol predominant plants E. P. M. de Meijer, K. M. Hammond Euphytica September 2005, Volume 145, Issue 1–2, pp 189–198  https://link.springer.com/article/10.1007/s10681-005-1164-8   


DNA polymorphisms in the tetrahydrocannabinolic acid (THCA) synthase gene in "drug-type" and "fiber-type" Cannabis sativa L. Kojoma M1, Seki H, Yoshida S, Muranaka T. Forensic Sci Int. 2006 Jun 2;159(2-3):132-40. Epub 2005 Sep 6. http://www.sciencedirect.com/science/article/pii/S037907380500407X?via%3Dihub   


Tetrahydrocannabinolic Acid Synthase, the Enzyme Controlling Marijuana Psychoactivity, is Secreted into the Storage Cavity of the Glandular Trichomes  Supaart Sirikantaramas Futoshi Taura Yumi Tanaka Yu Ishikawa Satoshi Morimoto Yukihiro Shoyama  Plant and Cell Physiology, Volume 46, Issue 9, 1 September 2005, Pages 1578–1582, https://doi.org/10.1093/pcp/pci166     


Genetics and Marker-assisted Selection of the Chemotype in Cannabis sativa L. Daniela Pacifico, Francesca Miselli, Mirta Micheler, Andrea Carboni, Paolo Ranalli, Giuseppe Mandolino Molecular Breeding   April 2006, Volume 17, Issue 3, pp 257–268 https://link.springer.com/article/10.1007/s11032-005-5681-x   


The inheritance of chemical phenotype in Cannabis sativa L. (III): variation in cannabichromene proportion E. P. M. de Meijer, K. M. Hammond, M. Micheler Euphytica January 2009, Volume 165, Issue 2, pp 293–311 https://link.springer.com/article/10.1007/s10681-008-9787-1     


Inheritance of chemical phenotype in Cannabis sativa L. (IV): cannabinoid-free plants [2009] de Meijer, E. P. M. Hammond, K. M. Sutton, A. http://agris.fao.org/agris-search/search.do?recordID=US201301642273   


Differentiation of drug and non-drug Cannabis using a single nucleotide polymorphism (SNP) assay. Rotherham D, Harbison SA. Forensic Sci Int. 2011 Apr 15;207(1-3):193-7. doi: 10.1016/j.forsciint.2010.10.006. Epub 2010 Oct 30. http://www.sciencedirect.com/science/article/pii/S0379073810004639?via%3Dihub   


Structure and function of ∆1-tetrahydrocannabinolic acid (THCA) synthase, the enzyme controlling the psychoactivity of Cannabis sativa. Shoyama Y, Tamada T, Kurihara K, Takeuchi A, Taura F, Arai S, Blaber M, Shoyama Y, Morimoto S, Kuroki R. J Mol Biol. 2012 Oct 12;423(1):96-105. doi: 10.1016/j.jmb.2012.06.030. Epub 2012 Jul 2. http://www.sciencedirect.com/science/article/pii/S0022283612005220?via%3Dihub     


A real-time PCR assay for the relative quantification of the tetrahydrocannabinolic acid (THCA) synthase gene in herbal Cannabis samples. Cascini F, Passerotti S, Martello S. Forensic Sci Int. 2012 Apr 10;217(1-3):134-8. doi: 10.1016/j.forsciint.2011.10.041. Epub 2011 Nov 16. http://www.sciencedirect.com/science/article/pii/S0379073811005299?via%3Dihub     


Analysis of THCA synthase gene expression in cannabis: a preliminary study by real-time quantitative PCR. Cascini F, Passerotti S, Boschi I. Forensic Sci Int. 2013 Sep 10;231(1-3):208-12. doi: 10.1016/j.forsciint.2013.05.019. Epub 2013 Jun 20. https://www.ncbi.nlm.nih.gov/pubmed/23890639    


Single molecule sequencing of THCA synthase reveals copy number variation in modern drug-type Cannabis sativa L. Kevin J McKernan, Yvonne Helbert, Vasisht Tadigotla, Stephen McLaughlin, Jessica Spangler, Lei Zhang, Douglas Smith doi: https://doi.org/10.1101/028654   


Sequence heterogeneity of cannabidiolic- and tetrahydrocannabinolic acid-synthase in Cannabis sativa L. and its relationship with chemical phenotype. Onofri C, de Meijer EPM, Mandolino G. Phytochemistry. 2015 Aug;116:57-68. doi: 10.1016/j.phytochem.2015.03.006. Epub 2015 Apr 9. http://www.sciencedirect.com/science/article/pii/S0031942215001181?via%3Dihub   


Gene duplication and divergence affecting drug content in Cannabis sativa   George D. Weiblen, Jonathan P. Wenger, Kathleen J. Craft, Mahmoud A. ElSohly, Zlatko Mehmedic, Erin L. Treiber, M. David Marks New Phytol. 2015 Dec;208(4):1241-50. doi: 10.1111/nph.13562. Epub 2015 Jul 17. 


The inheritance of chemical phenotype in Cannabis sativa L. (V): regulation of the propyl-/pentyl cannabinoid ratio, completion of a genetic model E. P. M. de Meijer, K. M. Hammond Euphytica July 2016, Volume 210, Issue 2, pp 291–307 https://link.springer.com/article/10.1007/s10681-016-1721-3