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The EndoCannabinoid System

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Isolation and structure of a brain constituent that binds to the cannabinoid receptor 

WA Devane, L Hanus, A Breuer, RG Pertwee, LA Stevenson, G Griffin, D Gibson, A Mandelbaum, A Etinger, R Mechoulam Science 18 Dec 1992: Vol. 258, Issue 5090, pp. 1946-1949; DOI: 10.1126/science.1470919 

http://science.sciencemag.org/content/258/5090/1946  


The Endocannabinoid System as an Emerging Target of Pharmacotherapy 

Pál Pacher, Sándor Bátkai and George Kunos Pharmacological Reviews September 2006, 58 (3) 389-462; 

DOI: https://doi.org/10.1124/pr.58.3.2   


The Endocannabinoid System and the Brain 

Raphael Mechoulam and Linda A. Parker Annual Review of Psychology Vol. 64:21-47 (Volume publication date January 2013)
https://doi.org/10.1146/annurev-psych-113011-143739    


The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders 

CristoforoSilvestri, VincenzoDi Marzo

https://doi.org/10.1016/j.cmet.2013.03.001   


The endocannabinoid system in guarding against fear, anxiety and stress 

Beat Lutz, Giovanni Marsicano, Rafael Maldonado & Cecilia J. Hillard Nature Reviews Neuroscience 16, 705–718 (2015), doi:10.1038/nrn4036 

https://www.nature.com/articles/nrn4036  


Are cannabidiol and Δ9-tetrahydrocannabivarin  negative modulators of the endocannabinoid system? A systematic review.  

McPartland, J. M., Duncan, M., Di Marzo, V. and Pertwee, R. G. (2015), Br J Pharmacol, 172: 737–753. doi:10.1111/bph.12944 

http://onlinelibrary.wiley.com/doi/10.1111/bph.12944/full