The EndoCannabinoid System


Isolation and structure of a brain constituent that binds to the cannabinoid receptor 

WA Devane, L Hanus, A Breuer, RG Pertwee, LA Stevenson, G Griffin, D Gibson, A Mandelbaum, A Etinger, R Mechoulam Science 18 Dec 1992: Vol. 258, Issue 5090, pp. 1946-1949; DOI: 10.1126/science.1470919 


The Endocannabinoid System as an Emerging Target of Pharmacotherapy 

Pál Pacher, Sándor Bátkai and George Kunos Pharmacological Reviews September 2006, 58 (3) 389-462; 

DOI: https://doi.org/10.1124/pr.58.3.2   

The Endocannabinoid System and the Brain 

Raphael Mechoulam and Linda A. Parker Annual Review of Psychology Vol. 64:21-47 (Volume publication date January 2013)

The Endocannabinoid System in Energy Homeostasis and the Etiopathology of Metabolic Disorders 

CristoforoSilvestri, VincenzoDi Marzo


The endocannabinoid system in guarding against fear, anxiety and stress 

Beat Lutz, Giovanni Marsicano, Rafael Maldonado & Cecilia J. Hillard Nature Reviews Neuroscience 16, 705–718 (2015), doi:10.1038/nrn4036 


Are cannabidiol and Δ9-tetrahydrocannabivarin  negative modulators of the endocannabinoid system? A systematic review.  

McPartland, J. M., Duncan, M., Di Marzo, V. and Pertwee, R. G. (2015), Br J Pharmacol, 172: 737–753. doi:10.1111/bph.12944